Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity.
نویسندگان
چکیده
منابع مشابه
architecture and engineering of nanoscale sculptured thin films and determination of their properties
چکیده ندارد.
15 صفحه اولStructural and functional dynamics of Excitatory Amino Acid Transporters (EAAT)
Glutamate transporters control the glutamate homeostasis in the central nervous system, and, thus, are not only crucial for physiological excitatory synaptic signaling, but also for the prevention of a large number of neurodegenerative diseases that are associated with excessive and prolonged presence of the neurotransmitter glutamate in the extracellular space. Until now, five subtypes of high...
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In mammalian cells, the uptake of amino acids is mediated by specialized, energy-dependent and passive transporters with overlapping substrate specificities. Most energy-dependent transporters are coupled either to the cotransport of Na+ or Cl- or to the countertransport of K+. Passive transporters are either facilitated transporters or channels. As a prelude to the molecular characterization o...
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We have identified the third member of a family of cationic amino acid transporters in lipopolysaccharidestimulated murine macrophages. The deduced amino acid sequence of this transporter is the same as MCAT-2 (mouse cationic amino acid transporter-Z), the low affinity transporter expressed in hepatocytes, except for a stretch of 41 amino acids that connects the eighth and ninth membrane-spanni...
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• The heavy subunits (molecular mass of ~90 and ~80 kDa for rBAT and 4F2hc, respectively) are type II membrane N-glycoproteins with a single transmembrane domain, an intracellular NH2 terminus, and an extracellular COOH terminus significantly homologous to insect and bacterial glucosidases (FIGURE 1). Recently, X-ray diffraction of the extracellular domain of human 4F2hc revealed a three-dimens...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2003
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.28.1